Our Ribosome Display Technology
Discover high-affinity peptides, antibodies, and protein binders with Rx Biosciences’ Ribosome Display Platform. Our fully cell-free selection system enables the construction and screening of ultra-high-diversity libraries (10¹³–10¹⁵ variants), accelerating the discovery of rare binders with exceptional affinity.
Unlike cell-based display technologies, ribosome display eliminates transformation limitations, allowing rapid selection and affinity maturation of peptides, antibody fragments, and proteins for therapeutic, diagnostic, and research applications.
Ready-to-Go Display Libraries
Accelerate your antibody and DARPin discovery with Rx Biosciences' ready-to-screen, high-diversity display libraries. Our validated libraries eliminate the time and cost of library construction, enabling rapid identification of high-affinity binders for research, diagnostics, and therapeutic development.
Available Libraries
Human Naïve scFv Ribosome Display Library
(Complexity >1 × 10¹⁴)
DARPins Ribosome Display Library
(Complexity >1 × 10¹⁰)
10¹³–10¹⁵ Library Diversity
Ultra-high-diversity libraries with up to 10¹⁵ variants.
Cell-Free Selection
Fully in vitro system with no transformation limitations.
High-Affinity Binder Discovery
Rapid identification of rare binders with exceptional affinity.
Affinity Maturation
Iterative selection for enhanced affinity and binding performance.
High-Throughput Screening
Streamlined workflows for fast, high-volume binder discovery.
OUR WORKFLOW
A streamlined, cell-free process to identify high-affinity binders in fewer rounds.
Library Construction
Construction of ultra-high-diversity DNA libraries
In Vitro Transcription & Translation
In vitro transcription and translation to generate ribosome-mRNA-protein complexes.
Target Binding & Ribosome Complex Formation
Target binding and Ribosome complex formation.
Washing & Enrichment
Washing and enrichment of high-affinity biners.
RNA Recovery, RT-PCR & Iterative Selection
RNA Recovery, RT-PCR amplification, and iterative selection by subcloning in an expression vector followed by lysate ELISA.
DNA Sequencing & Candidate Identification
DNA Sequencing and Candidate identification.
Final Validation
Final validation by FACS, ELISA, and Biacore.
This completely cell-free workflow enables rapid screening while preserving enormous library diversity.
SERVICE HIGHLIGHTS
- Ultra-high-diversity libraries (10¹³–10¹⁵ variants)
- Antibody, peptide, protein, DARPins and cDNA libraries
- Libraries of immunized animals
- Custom-designed synthetic libraries
- Peptide libraries of multiple lengths
- Rapid enrichment of high-affinity binders
- Cell-free selection and affinity maturation
- DNA sequencing and lead identification
APPLICATIONS
- Therapeutic Antibody Discovery
- Peptide Ligand Discovery
- Protein Engineering
- Affinity Maturation
- Epitope Mapping
- Biomarker Discovery
- Diagnostic Reagent Development
- Protein–Protein Interaction Studies
PLATFORM ADVANTAGES
- Cell-free selection system with no transformation limitations
- Library diversity up to 10¹⁵ variants
- Rapid identification of picomolar-affinity binders
- Efficient enrichment through iterative selection
- Compatible with antibody, peptide, protein, DARPins and cDNA libraries
- Customized workflows tailored to your research goals
Why Choose Rx Biosciences?
With extensive expertise in display technologies, Rx Biosciences delivers reliable, high-throughput ribosome display solutions that accelerate lead discovery and optimization. From custom library design to sequencing and candidate validation, our scientists provide end-to-end support for your research and therapeutic development programs.
Accelerate Your Ligand Discovery with Ribosome Display
Partner with Rx Biosciences to identify high-affinity antibodies, peptides, and protein binders using our ultra-high-diversity ribosome display platform.