Our Yeast Display Technology

High-throughput binder (antibody, ligand, target, receptor) discovery and affinity maturation using advanced yeast display technology.

Yeast display is a powerful eukaryotic screening platform for discovering and optimizing high-affinity antibodies. Unlike phage display, yeast display enables proper protein folding and post-translational modifications, producing antibodies that more closely resemble their native human forms. Combined with fluorescence-activated cell sorting (FACS), this technology enables rapid, high-throughput selection of the highest-affinity binders.

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Ready-to-Go Display Libraries

Accelerate your antibody and DARPin discovery with Rx Biosciences' ready-to-screen, high-diversity display libraries. Our validated libraries eliminate the time and cost of library construction, enabling rapid identification of high-affinity binders for research, diagnostics, and therapeutic development.

Available Libraries

Human Naïve scFv Yeast Display Library

(Complexity >1 × 10¹²)

OUR WORKFLOW

Library Construction

Construction of high-diversity yeast display libraries (nanobodies, scFvs, miniproteins)

Antigen Binding

Antigen binding under increasing selection stringency

High-Resolution Screening

High-resolution screening using MACS and FACS

Clone Isolation

Isolation of high-affinity antibody clones with binding constants (Mean Binding Affinity)

Antibody Purification

Antibody purification for downstream characterization

Our scientists customize each project to meet your research objectives,
delivering reliable, reproducible, and high-quality screening results.

APPLICATIONS
  • Discovery of Therapeutic Monoclonal Antibody
  • Identification of high affinity binders from Mini Protein libraries and functional validation
  • Global protein stability studies
  • Antibody Affinity Maturation
PLATFORM FEATURES
  • Eukaryotic expression system
  • Native protein folding and post-translational modifications
  • High-diversity antibody libraries
  • High-throughput MACS/FACS screening
  • Illumina MiSeq NGS platform
  • Validation by flowcytometry, ELISA and Biacore
  • Experienced scientific support from project design through lead selection

Ready to accelerate your antibody discovery?

Partner with Rx Biosciences for fast, cost-effective, and reliable yeast display screening solutions.