Ligand Discovery & Affinity Maturation

At Rx Biosciences, our ligand discovery and affinity maturation services help you identify ideal ligands for your target molecules efficiently. We either screen existing libraries or rapidly prepare a customized phage display library tailored to your needs for ligand screening. Our ligand discovery and affinity maturation approach ensures that you receive ligands with optimal binding properties.

Once potential ligands are identified, we rigorously test their binding affinity under various denaturing conditions. These tests evaluate how ligand-target interactions respond to changes in stability, binding strength, and ligand leaching from ligand-bound resins. Such comprehensive analysis is crucial for designing affinity columns that efficiently purify proteins, vaccines, drugs, and other valuable compounds through affinity chromatography.

Additionally, Rx Biosciences can label the purified ligands with enzymes or fluorescent groups, enabling their use in both cell-free and cell-based assays. This labeling facilitates detailed studies on ligand function and interaction in diverse biological settings.

Our expertise in ligand discovery and affinity maturation supports your research and development goals by delivering high-quality ligands that improve purification processes and assay performance. Whether your focus is on drug development, vaccine production, or protein purification, our tailored services provide reliable and effective solutions.

By combining innovative screening methods and thorough binding analysis, Rx Biosciences ensures that your affinity maturation process results in ligands with superior stability and target specificity. Our commitment to quality helps accelerate your project timelines while maintaining precision and reproducibility.